Optimal Dose or Optimal Exposure? Consideration for Linezolid in Tuberculosis Treatment
نویسندگان
چکیده
منابع مشابه
Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy
UNLABELLED Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis. Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhibition of mitochondrial protein synthesis. Clinically relevant linezolid regimens were simulated in the in vitro hollow-fiber infection model (HFIM) system to identify the l...
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inflammation in asthma and chronic obstructive pulmonary disease. Ann NY Acad Sci 2003; 992: 218–230. 18 Joos G, Pauwels R, Van Der Straten M. The effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax 1987; 42: 779–783. 19 Wiedermann FJ, Kahler CM, Reinisch N, et al. Induction of normal human eosinophil migration in vitro by substance P. Acta Hae...
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Intermittent tuberculosis treatment regimens have been developed to facilitate treatment supervision. Their efficacy has been substantiated by clinical trials and tuberculosis control programmes, notwithstanding the lack of head-to-head comparison between daily and intermittent regimens. Recently, there has been opposing evidence from observational studies, pharmacokinetic-pharmacodynamic studi...
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Tuberculosis (TB) is a disease found in about one third of the world population. There is some controversy on the role of exogenous reinfection; with some epidemiologists supporting it while others consider it irrelevant. However, even at a minimal level, the presence of exogenous reinfection is capable of generating hysteresis and supporting multiple endemic states when the basic reproduction ...
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uncertainty in the financial market will be driven by underlying brownian motions, while the assets are assumed to be general stochastic processes adapted to the filtration of the brownian motions. the goal of this study is to calculate the accumulated wealth in order to optimize the expected terminal value using a suitable utility function. this thesis introduced the lim-wong’s benchmark fun...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2020
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00287-20